Naltrexone: Online Purchase
56 (2020) Naltrexone: Online Purchase. En: Segundo Encuentro En Línea CHAT: Ciudadanía y mediación digital. . Extenso de congreso. Recuperado de: https://elchat2.edusol.info/elchat/extenso/naltrexone-online
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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, provided that they also experience weight-related health problems such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder in addition to being an aid to smoking cessation treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that features a reduced-calorie diet and exercise, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical activity. Results from a medical trial that enrolled patients without diabetes established that patients had a typical weight loss of 4.1% instead of participants who were given placebos) after a 12- month period, while a different study involving patients with diabetes had an average weight loss of 2% over treatment with placebo at one full year. Using two separate drugs to lose weight naturally can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it one should err assisting caution and allow the FDA do its job and demand some research be done so the public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on the medications. Researchers discovered that participants using this drug to get a year, dropped a few pounds within four weeks and have kept the body weight off through the 56 weeks in the study. Contrave is often a combination of the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which are made up of multiple active ingredient, that might make them more effective and safer. Combo-pilling may be the newest fad or even better the newest in the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that since right now there are not any long term prescription diet pills that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug may also raise blood pressure level and heartbeat, and mustn't be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients for the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation. The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.